BPC-157 and Ascorbic Acid for Acute Pancreatitis and EPI
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BPC-157 has shown protective effects in rat studies on acute pancreatitis. It reduces inflammation, swelling, tissue death, and bleeding in the pancreas, while also lowering elevated amylase levels. It appears to work by improving blood flow and reducing thrombosis.
High-dose ascorbic acid, or vitamin C, has produced similar benefits in animal models. It reduces inflammation, oxidative stress, and pancreatic damage, and has been shown to lower amylase and lipase levels. In humans, it shortens hospital stays but hasn’t clearly reduced organ failure or mortality.
In online forums, some people with chronic pancreatitis or EPI report that BPC-157 helps with pain, digestion, and in a few cases, reduced their need for enzymes like Creon. Results are mixed — not everyone sees benefit. There are some anecdotal reports on high-dose vitamin C specifically for EPI, though some people use it as a general antioxidant support.
• Sikiric P, et al. (1996). “Salutary and prophylactic effect of pentadecapeptide BPC 157 on acute pancreatitis and concomitant gastroduodenal lesions in rats.” Digestive Diseases and Sciences. https://pubmed.ncbi.nlm.nih.gov/8689934/
• Gao L, et al. (2021). “The Challenges and Effects of Ascorbic Acid Treatment of Acute Pancreatitis: A Systematic Review and Meta-Analysis of Preclinical and Clinical Studies.” Frontiers in Nutrition. https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.734558/full
• Xu LL, et al. (2020). “High-dose vitamin C alleviates pancreatic injury via the NRF2/NQO1/HO-1 pathway in a rat model of severe acute pancreatitis.” Annals of Translational Medicine.
Ascorbic acid:
https://www.junipershealth.co.uk/products/fine-vitamin-c-powder-500g
or liposomal C
https://www.junipershealth.co.uk
